Kidney TransplantationArchives
Replacing Mycophenolate Mofetil by Everolimus in Kidney Transplant Recipients to Increase Vaccine Immunogenicity: Results of a Randomized Controlled Trial
Kidney Transplantation 1 min.
Vaccine immunogenicity is reduced in kidney transplant recipients (KTRs), especially in those using mycophenolate mofetil (MMF). Whether replacement of MMF by everolimus improves vaccine immunogenicity is unknown. Methods: KTRs were randomized 1:1 to continue MMF or switch to everolimus. Participants...
Intravenous trimethoprim–sulfamethoxazole desensitization as a therapeutic strategy for late-onset Pneumocystis jirovecii pneumonia in a kidney transplant recipient: a case report
Kidney Transplantation 2 min.
Kidney transplantation is the most effective treatment option for end-stage renal disease. However, chronic antibody-mediated rejection (cAMR) remains one of the major causes limiting long-term graft survival [1]. High-dose corticosteroids, intravenous immunoglobulin (IVIG), and rituximab are frequently...
COVID-19 boosters restore virus-specific immune responses in kidney transplant recipients unresponsive to primary vaccination
Kidney Transplantation 8 min.
Due to the lifelong immunosuppressive therapies required to prevent transplant rejection, KTRs exhibit impaired immune responses to vaccination against pathogens such as hepatitis B, influenza virus, and Streptococcus pneumoniae1. The implications of this impaired vaccine responsiveness became...
Prehabilitation interventions to support the postoperative recovery of adult kidney transplant candidates: a scoping review
Kidney Transplantation 5 min.
Approximately four million Canadians are affected by chronic kidney disease (CKD) [1]. CKD is a gradual loss of kidney function over time which can progress to end stage kidney disease (ESKD), a condition that affects about 48,375 Canadians [2]. While there is no cure for kidney failure, renal replacement...
Evaluation of everolimus pharmacokinetic monitoring based on trough concentration and area under the blood concentration time curve in kidney transplantation
Kidney Transplantation 4 min.
Everolimus (EVR) is a proliferation-signal inhibitor developed as an immunosuppressive therapy following solid-organ transplantation. Among kidney transplant recipients (KTRs), calcineurin inhibitor (CNI)-associated nephrotoxicity remains a major barrier to long-term graft survival. EVR has emerged as...
