
End-stage chronic kidney disease (CKD) is a significant concern for older adults and is often associated with cognitive impairment (CI). The origin of this CI is multifactorial, involving vascular and metabolic factors. Additionally, renal treatments, including dialysis, may affect cognition. This study...

Kidney transplantation is the preferred therapy for end-stage renal disease (ESRD), yet long-term graft survival remains limited. Effective preservation of transplanted kidneys is essential amid a persistent organ shortage. Post-transplant graft injury arises from both immune and nonimmune mechanisms....

Vaccine immunogenicity is reduced in kidney transplant recipients (KTRs), especially in those using mycophenolate mofetil (MMF). Whether replacement of MMF by everolimus improves vaccine immunogenicity is unknown. Methods: KTRs were randomized 1:1 to continue MMF or switch to everolimus. Participants...

Kidney transplantation is the most effective treatment option for end-stage renal disease. However, chronic antibody-mediated rejection (cAMR) remains one of the major causes limiting long-term graft survival [1]. High-dose corticosteroids, intravenous immunoglobulin (IVIG), and rituximab are frequently...