Acute & Chronic Kidney InjuryArchives
Predictors of acute kidney injury following the first cycle of high-dose methotrexate in patients with hematological malignancies
Consensus regarding predictors of acute kidney injury (AKI) following high-dose methotrexate (HDMTX) across diverse patient populations remains inconsistent. We conducted a retrospective study to identify predictors of AKI in adult patients with hematological malignancies receiving the first cycle of...
Diagnosis, diagnostic approach and challenges in pregnancy-associated AKI-the ADQI 32 consensus meeting
Despite advancements in obstetric care, pregnancy-associated acute kidney injury (PrAKI) continues to be a significant public health concern, contributing to substantial maternal and fetal morbidity and mortality. The most common causes of PrAKI include preeclampsia/eclampsia, haemorrhage and infection....
Practice patterns and outcomes in cancer patients developing immune checkpoint inhibitors-related AKI
Acute kidney injury (AKI) is a known immune-related adverse event of cancer immune checkpoint inhibitor (ICI) therapy. Further population-based data on AKI incidence, risk factors and practice patterns post-ICI therapy are needed. Methods: We measured the cumulative incidence of AKI among advanced cancer...
Pathophysiology, risk factors and clinical management for polymyxin-associated acute kidney injury
Polymyxins serve as a 'last-line' defence against Gram-negative bacterial infections and are frequently used in critically ill patients with multidrug-resistant pathogens. However, polymyxin-associated acute kidney injury (PA-AKI) remains a major factor limiting their clinical application. This review...
Recombinant alpha-1 microglobulin to improve outcomes in survivors of AKI
Acute kidney injury (AKI) is a serious and common complication among patients undergoing major surgery. The underlying pathophysiologic mechanism includes ischemia-reperfusion injury, complement activation, oxidative stress, and heme toxicity. Among potential preventive measures, recombinant alpha-1...
