Acute & Chronic Kidney InjuryArchives
Cell-free hemoglobin is associated with microcirculatory perfusion disturbances and acute kidney injury in rats on extracorporeal membrane oxygenation
Extracorporeal membrane oxygenation (ECMO) provides support in case of potentially reversible cardiac and/or respiratory failure, refractory to conventional therapies. Despite technological advancements, morbidity and mortality remain high, with overall survival rates around 50% [1]. Among the most frequent...
Uncovering molecular markers of the microvascular endothelial response in sepsis-associated acute kidney injury: a translational study in mice and humans
Sepsis is a life-threatening host response to an infection often complicated by acute kidney injury, also known as sepsis-associated acute kidney injury (SA-AKI). The occurrence of SA-AKI is strongly associated with increased morbidity and mortality [1, 2–3]. Despite considerable heterogeneity...
Norepinephrine ameliorates sepsis-associated acute kidney injury through inhibiting damage of renal tubular epithelium induced by macrophage inflammatory response
Sepsis-associated acute kidney injury (SA-AKI) is one of the most frequent and severe complications in patients with sepsis [1, 2]. Research indicated its clinical incidence is approximately 40–50% [3, 4–5]. Furthermore, SA-AKI is an independent risk factor for poorer outcomes in patients...
Evaluation of risk factors and outcomes of neonates with hypoxic ischemic encephalopathy and acute kidney injury
Neonatal hypoxic-ischaemic encephalopathy (HIE) is a serious neurological disorder that presents during or after birth due to fetal asphyxia [1, 2]. It has been associated with significant mortality, and the only current treatment for neonates meeting a specific threshold is hypothermia [1, 3]. HIE results...
Relationship between intra-bladder pressure and acute kidney injury in patients with acute pancreatitis: interpretable machine learning approach
Acute pancreatitis (AP) is a local inflammatory reaction in the pancreas, with prolonged hospitalization and high treatment costs, and it is also one of the main causes of hospital death [1, 2]. The global incidence rates of AP range from 4.9 to 73.9 per 100,000 individuals, and the annual incidence...
