Acute & Chronic Kidney InjuryArchives
Predictive value of miR-132-3p for the onset of sepsis-induced acute kidney injury and its functional role during disease development
Sepsis-induced acute kidney injury (SI-AKI) is a prevalent critical complication characterized by delayed early diagnosis, inadequate prognosis evaluation, and unclear pathogenesis. MicroRNAs (miRNAs) are promising SI-AKI biomarkers, yet their regulatory roles remain undefined. To clarify the diagnostic...
QT-prolonging medications: prevalence of use and associated risks in CKD
Chronic kidney disease (CKD) affects >10% of the global adult population and is associated with substantial cardiovascular morbidity and mortality. Sudden cardiac death (often precipitated by ventricular arrhythmias like torsades de pointes) is a leading cause of death in patients with CKD. Prolongation...
Comparison of SII, NLR, and SIRI for severity stratification and prognosis in sepsis-related acute kidney injury
Sepsis-associated acute kidney injury (SA-AKI) is a severe complication linked to excessive systemic inflammation and immune dysregulation, with high mortality and poor prognosis. To compare the predictive efficacy of the Systemic Immune-Inflammation Index (SII), Neutrophil-to-Lymphocyte Ratio (NLR),...
Predictors of acute kidney injury following the first cycle of high-dose methotrexate in patients with hematological malignancies
Consensus regarding predictors of acute kidney injury (AKI) following high-dose methotrexate (HDMTX) across diverse patient populations remains inconsistent. We conducted a retrospective study to identify predictors of AKI in adult patients with hematological malignancies receiving the first cycle of...
Diagnosis, diagnostic approach and challenges in pregnancy-associated AKI-the ADQI 32 consensus meeting
Despite advancements in obstetric care, pregnancy-associated acute kidney injury (PrAKI) continues to be a significant public health concern, contributing to substantial maternal and fetal morbidity and mortality. The most common causes of PrAKI include preeclampsia/eclampsia, haemorrhage and infection....
