Acute & Chronic Kidney InjuryArchives
Early osmotherapy exposure and subsequent incident acute kidney injury in neurocritical care patients: a MIMIC-IV retrospective cohort study
Osmotherapy is frequently used in neurocritical care to manage cerebral edema and intracranial hypertension. However, its association with subsequent new-onset acute kidney injury (AKI), and whether early serum sodium or chloride burden materially attenuates this association, remain uncertain. Methods:...
The neutrophil-to-lymphocyte ratio as a predictive marker for acute kidney injury in hospitalized sepsis patients: a prospective cohort study
Sepsis-associated acute kidney injury (SA-AKI) is a frequent and severe complication of sepsis that substantially increases morbidity and mortality. The neutrophil-to-lymphocyte ratio (NLR), obtained from routine complete blood counts, has emerged as a potential early inflammatory marker; however, its...
Estimated glucose disposal rate outperforms conventional insulin resistance indices in predicting acute kidney injury risk among individuals with diabetes and prediabetes
Acute kidney injury (AKI) is a major global health concern, particularly in individuals with diabetes or prediabetes. While insulin resistance (IR) is implicated in AKI pathogenesis, the relationship between comprehensive IR measures-particularly the estimated glucose disposal rate (eGDR)-and AKI risk...
Immunoinflammatory biomarkers for sepsis-associated acute kidney injury: a multicenter prospective cohort study
Immune dysregulation is central to sepsis-related organ injury, yet standard clinical indicators show limited predictive value for sepsis-associated acute kidney injury (SA-AKI) in older adults(aged ≥ 65 years). This study evaluated whether immuno-inflammatory biomarkers improve early prediction of...
