Acute & Chronic Kidney InjuryArchives
Prognostic value of modified KDIGO staging for acute kidney injury in neonates: a prospective observational study in a level IIIB NICU
Acute kidney injury in neonates is increasingly recognised as a significant contributor to morbidity and mortality in neonatal intensive care units particularly in low- and middle-income countries where diagnostic limitations and variable definitions have historically hindered accurate reporting and...
LCN2 and TIMP1 as senescence-associated biomarkers in sepsis-induced AKI and their relationship with immune infiltration
Immune cells are key drivers of acute kidney injury (AKI) due to the complex interaction between immune cells, senescence and AKI. Three AKI-related datasets were sourced from the Gene Expression Omnibus (GEO) database, encompassing experimental data and gene expression arrays. TIMP1 and LCN2 were used...
Predictive value of miR-132-3p for the onset of sepsis-induced acute kidney injury and its functional role during disease development
Sepsis-induced acute kidney injury (SI-AKI) is a prevalent critical complication characterized by delayed early diagnosis, inadequate prognosis evaluation, and unclear pathogenesis. MicroRNAs (miRNAs) are promising SI-AKI biomarkers, yet their regulatory roles remain undefined. To clarify the diagnostic...
QT-prolonging medications: prevalence of use and associated risks in CKD
Chronic kidney disease (CKD) affects >10% of the global adult population and is associated with substantial cardiovascular morbidity and mortality. Sudden cardiac death (often precipitated by ventricular arrhythmias like torsades de pointes) is a leading cause of death in patients with CKD. Prolongation...
