Pediatric TransplantArchives
Targeted strategies for pediatric cancer and post-transplant fever: the role of host and pathogen biomarkers.
Pediatric Transplant 1 min.
Host and pathogen biomarkers may lead to improved management of fever in children with cancer and post hematopoietic cell transplant (HCT). This review summarizes current evidence on biomarkers for predicting infections. Recent findings: Host biomarkers show promise for distinguishing between infectious...
Primary hyperoxaluria: insights into its clinical presentation, genetic mutations, and transplantation outcomes in a pediatric population in a tertiary care center
Pediatric Transplant 3 min.
Primary hyperoxaluria (PH) is a rare inherited disorder characterized by oxalate overproduction in blood and urine due to defects in glyoxylate metabolism (see supplementary file 1), leading to recurrent kidney stones, nephrocalcinosis, and progressive kidney damage. Among its three known subtypes, namely...
Development and prospective evaluation of a machine learning model to predict vomiting among pediatric cancer and hematopoietic cell transplant patients
Pediatric Transplant 5 min.
Vomiting is one of the most common symptoms experienced by pediatric cancer and hematopoietic cell transplant (HCT) patients, with substantial negative impacts on quality of life [1, 2]. Vomiting can reduce oral intake, worsen nutritional status, lead to hospitalization and increase healthcare costs...
A cohort of allogeneic hematopoietic stem cell transplantation for pediatric rare diseases (allo-HSCT-PRD): design and preliminary results
Pediatric Transplant 4 min.
According to the China Rare Disease Definition Study Report 2021, rare diseases are defined as those with an incidence rate of fewer than 1 in 10,000 live births, a prevalence rate below 1 in 10,000, or a total affected population not exceeding 140,000 individuals within the national population. Orphanet,...
Concomitant Azole Initiation Decreases Time to Stable Goal Sirolimus Concentrations in Pediatric Allogeneic Transplant Recipients.
Pediatric Transplant 1 min.
Variability of sirolimus pharmacokinetics, often compounded by interactions with azole antifungal therapy, leads to concentrations outside the goal range and increased risk of related complications. We assessed the time to initial attainment of stable goal sirolimus concentrations in patients who either...
