Epilepsy and SeizuresArchives
Personalised selection of medication for newly diagnosed adult epilepsy: study protocol of a first-in-class, double-blind, randomised controlled trial
Epilepsy and Seizures 5 min.
Multisite, prospective, double-blind, randomised, controlled trial of a machine learning model for antiseizure medication (ASM) selection for newly diagnosed epilepsy. Besides measuring the cost-effectiveness of applying the machine learning model, the acceptance of machine learning-assisted clinical...
Novel compound heterozygous mutations in LMAN2L cause early childhood refractory epilepsy
Epilepsy and Seizures 6 min.
Autosomal recessive mental retardation 52 (MRT52, OMIM: 616887) was first reported in 2016, and it is characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period [1]. Autosomal recessive...
Leveraging pretrained language models for seizure frequency extraction from epilepsy evaluation reports
Epilepsy and Seizures 8 min.
Epilepsy affects more than 3.4 million people in the United States and 65 million globally. Even with the availability of various treatments, 4 out of 10 individuals with epilepsy will continue to have uncontrolled seizures ( https://www.epilepsy.com/stories/number-people-...). Sudden Unexpected Death...
The response to anti-seizure medications and the development of pharmacoresistant epilepsy in malformations of cortical development
Epilepsy and Seizures 5 min.
Malformations of cortical development (MCD) encompass a group of congenital disorders that disrupt normal brain cortical development due to genetic, infectious, vascular, or metabolic factors [1, 2–3]. Based on the disruption of key stages of cortical development, MCD are classified into three...
Effect of environmental pollutants particulate matter (PM2.5, PM10), nitrogen dioxide (NO2), sulfur dioxide (SO2), carbon monoxide (NO) and ground level ozone (O3) on epilepsy
Epilepsy and Seizures 4 min.
The extensive damage caused by ambient air pollution on human health has been well-documented in the scientific literature. The initial investigations focused on respiratory, cardiovascular, and cerebrovascular systems [1, 2–3]. However, recent studies have highlighted the deleterious impacts of...
