Hemorrhage and thrombosis in COVID-19-patients supported with extracorporeal membrane oxygenation: an international study based on the COVID-19 critical care consortium

  • Published on 07/08/2024
  •  Reading time: 5 min.

Feth Maximilian 1, Weaver Natasha 2,3, Fanning Robert B. 4,5, Cho Sung-Min 6,7, Griffee Matthew J. 8,9, Panigada Mauro 10, Zaaqoq Akram M. 11, Labib Ahmed 12, Whitman Glenn J. R. 6, Arora Rakesh C. 13,14, Kim Bo S. 6, White Nicole 2, Suen Jacky Y. 15,16,19, Li Bassi Gianluigi 15,17,18,19, Peek Giles J. 20, Lorusso Roberto 21, Dalton Heidi 22, Fraser John F. 15,16,17,18,19, Fanning Jonathon P. 15,16,17,23,24, the COVID-19 Critical Care Consortium, Bassi Gianluigi Li, Suen Jacky Y., Dalton Heidi J., Laffey John, Brodie Daniel, Fan Eddy, Torres Antoni, Chiumello Davide, Elhazmi Alyaa, Hodgson Carol, Ichiba Shingo, Luna Carlos, Murthy Srinivas, Nichol Alistair, Ng Pauline Yeung, Ogino Mark, Marwali Eva, Grasselli Giacomo, Bartlett Robert, Burrell Aidan, Elhadi Muhammed, Motos Anna, Barbé Ferran, Zanella Alberto, Fraser John F.

1 Department of Anesthesiology, Intensive Care Medicine, Emergency Medicine, and Pain Medicine German Armed Forces Hospital Ulm Ulm Germany
2 Queensland University of Technology Brisbane QLD Australia
3 https://ror.org/00eae9z71 School of Medicine and Public Health The University of Newcastle New South Wales Australia
4 https://ror.org/001kjn539 St. Vincent’s Hospital Melbourne VIC Australia
5 https://ror.org/01ej9dk98 Faculty of Medicine University of Melbourne Victoria Australia
6 Division of Cardiac Surgery, Department of Surgery Johns Hopkins School of Medicine Baltimore MD USA
7 Division of Neuroscience Critical Care, Department of Neurology and Neurosurgery Johns Hopkins School of Medicine Baltimore MD USA
8 https://ror.org/03r0ha626 Department of Anesthesiology and Perioperative Medicine, Sections of Critical Care and Perioperative Echocardiography University of Utah Salt Lake City UT USA
9 Anesthesiology Service Veteran Affairs Medical Center Salt Lake City UT USA
10 Department of Anesthesia Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico Di Milano, Intensive Care and Emergency Milano Lombardia Italy
11 https://ror.org/0153tk833 Department of Anaesthesiology, Division of Critical Care Medicine University of Virginia Charlottesville VA USA
12 Medical Intensive Care Unit, Department of Medicine Hamad General Hospital, Hamad Medical Corporation Doha Qatar
13 Harrington Heart & Vascular Institute University Hospitals Cleveland Medical Center Cleveland OH USA
14 https://ror.org/051fd9666 Case Western Reserve University School of Medicine Cleveland OH USA
15 https://ror.org/02cetwy62 Critical Care Research Group, Level 3, Clinical Sciences Building The Prince Charles Hospital 4032 ChermsideBrisbane QLD Australia
16 https://ror.org/00rqy9422 Faculty of Medicine University of Queensland Brisbane Australia
17 Intensive Care Unit St Andrew’s War Memorial Hospital, UnitingCare Health Spring Hill QLD Australia
18 https://ror.org/018kd1e03 Intensive Care Unit The Wesley Hospital, UnitingCare Health Auchenflower QLD Australia
19 https://ror.org/00rqy9422 Institute for Molecular Bioscience The University of Queensland St Lucia QLD Australia
20 https://ror.org/02y3ad647 Congenital Heart Centre University of Florida Gainesville FL USA
21 https://ror.org/02d9ce178 Cardiothoracic Surgery Department, Heart and Vascular Centre Maastricht University Medical Centre, and Cardiovascular Research Institute Maastricht Maastricht Netherlands
22 https://ror.org/0212h5y77 Heart and Vascular Institute Inova Fairfax Hospital Falls Church VA USA
23 https://ror.org/052gg0110 Nuffield Department of Population Health University of Oxford Oxford UK
24 https://ror.org/023331s46 The George Institute for Global Health Sydney NSW Australia


Background Extracorporeal membrane oxygenation (ECMO) is a rescue therapy in patients with severe acute respiratory distress syndrome (ARDS) secondary to COVID-19. While bleeding and thrombosis complicate ECMO, these events may also occur secondary to COVID-19. Data regarding bleeding and thrombotic events in COVID-19 patients on ECMO are sparse.
Methods Using the COVID-19 Critical Care Consortium database, we conducted a retrospective analysis on adult...


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