The role of infections and inflammation in schizophrenia: review of the evidence

  • Published on 06/02/2024
  •  Reading time: 6 min.

Ahmed Gellan K. 1, Ramadan Haidi Karam-Allah 2, Elbeh Khaled 1, Haridy Nourelhoda A. 1,3

1 https://ror.org/01jaj8n65 Department of Neurology and Psychiatry Assiut University Hospital, Faculty of Medicine Assiut Egypt
2 https://ror.org/01jaj8n65 Department of Tropical Medicine and Gastroenterology, Faculty of Medicine Assiut University Assiut Egypt
3 Department of Neuromuscular Disorders UCL Institute of Neurology WC1N 3BG Queen Square London UK

Abstract

Background Schizophrenia is a severe mental illness affecting approximately 1% of the population worldwide. While its exact causes remain unknown, emerging evidence suggests that infections and inflammation may contribute to disease development in a subset of individuals. This review comprehensively summarizes the evidence linking infections, immune system dysfunction, and schizophrenia risk.
Main body Several population-based studies have linked serious...

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