Kidney transplant candidates’ perspectives on the implementation of a Canadian Willingness to Cross program: A strategy to increase access to kidney transplantation for highly sensitized patients

Published on 06/05/2024

Reading time: 6 min.

Aliya Affdal^1,2, Mohamad Issa³, Fabian Ballesteros¹, Marie‐Françoise Malo^1,2, Gurvir Thind⁴, Teresa Atkinson⁴, Kristi Coldwell^4,5, Kuljit Grewal⁴, KaYee Wong⁴, James H. Lan^4,6, Marie‐Chantal Fortin ^1,2,6,7

¹ Centre de recherche du Centre hospitalier de l'Université de Montréal Montréal Canada
² Bioethics Program École de santé publique de l'Université de Montréal Montréal Canada
³ Faculté de médecine et des sciences de la santé Université de Sherbrooke Sherbrooke Canada
⁴ Faculty of Medicine University of British Columbia Vancouver Canada
⁵ Transplant Research Foundation of British Columbia Vancouver Canada
⁶ Canadian Donation and Transplantation Research Program Edmonton Canada
⁷ Faculté de médecine Université de Montréal Montréal Canada

Abstract

Background Kidney transplantation is the optimal treatment for end‐stage renal disease. However, highly sensitized patients (HSPs) have reduced access to transplantation, leading to increased morbidity and mortality on the waiting list. The Canadian Willingness to Cross (WTC) program proposes allowing transplantation across preformed donor specific antibodies (DSA) determined to be at a low risk of rejection under the adaptive design framework. This study collected...

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