Pharmacokinetic review of janus kinase inhibitors and its clinical implications for the management of rheumatoid arthritis

Published on 07/05/2024

Reading time: 4 min.

S. Chandrashekara ^*

Department of Clinical Immunology and Rheumatology, ChanRe Rheumatology and Immunology Center and Research, Bengaluru, India

CONTACT S. Chandrashekara mailto:chandrashekara_s@yahoo.com Department of Clinical Immunology and Rheumatology, ChanRe Rheumatology and Immunology Center and Research, 20th Main Rd, near Rajajinagar, West of Chord Road 2nd Stage, Rajajinagar, Bengaluru, Karnataka 560010, India

Abstract

Introduction In the realm of autoimmune rheumatic diseases, understanding JAK inhibitors (JAKi) nuances is vital. Baricitinib, tofacitinib, upaacitinib, filgotinib, and peficitinib exhibit subtle yet impactful pharmacokinetic (PK) and pharmacodynamic (PD) variations.
Areas covered This narrative review critically assesses PK and PD distinctions among globally approved JAKi for rheumatoid arthritis, which primarily guide clinical decisions in autoimmune...

To continue reading this article in Full-Text...

Access request*

* Access is totally free, without commitment or condition. Service exclusively reserved for healthcare professionals.

Expert opinion on drug metabolism & toxicology

Peer-Reviewed Journals A-Z

Search | Advanced search

Get the latest news in Rheumatology

Receive our newsletter to stay up to date with the latest news in Rheumatology

Access request

From peer-reviewed journals in Rheumatology

[space]	Find documents with all the words specified. dopamine homeostasis will get documents with dopamine and homeostasis, found documents must contain the two elements.
OR	Find documents with at least one of the words specified. dopamine OR homeostasis will get documents with word dopamine or homeostasis.
-	The sign - exclude the documents with word or expression specified. dopamine - homeostasis will get the documents with dopamine but without homeostasis. The sign - must be used with others operators.
" "	Find the documents with exactly the expression between the two quotation marks. Example: "symptomatic medication" will find only the documents with "symptomatic medication" in the document.
( )	Brackets are used to group words in a sub expression: (dopamine homeostasis) OR (ergotamine headache)
*	Asterisk is the truncation operator. It can be used as a prefix (with quotation marks) or suffix. *dopa homeo, dopne or "cature"*.