Reverse aging to treat lupus

  • Published on 07/26/2024
  •  Reading time: 2 min.

Wenliang Pan , George C. Tsokos

Department of Medicine Beth Israel Deaconess Medical Center and Harvard Medical School Boston Massachusetts USA

Abstract

Systemic lupus erythematosus (SLE) is a complex autoimmune disease with multifaceted pathogenetic processes, including abnormalities of T‐cell subset distribution and function. Accumulation of senescent CD4+ T cells has been found to contribute to the development of the disease. In this issue, Jiang et al. provide compelling evidence that links an expanded pool of CD4+CD57+ senescent T cells in patients with SLE to disease activity favored...

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