Relationship Between Quantitative Magnetic Resonance Imaging Measures and Functional Changes in Patients With Duchenne Muscular Dystrophy
- Published on 01/10/2025
- Reading time: 5 min.
Sarah P. Sherlock 1, Allison McCrady 2, Jeffrey Palmer 1, Haleh Aghamolaey 3, André Ahlgren 4, Per Widholm 4, Olof Dahlqvist Leinhard 4, Markus Karlsson 4
1
Pfizer Inc
Cambridge
Massachusetts
USA
2
Department of Biomedical Engineering
University of Virginia
Charlottesville
Virginia
USA
3
Department of Statistics
Quanticate Clinical Research Organization
Ontario
Canada
4
AMRA Medical AB
Linköping
Sweden
Abstract
Introduction/Aims Improved methodologies to monitor the progression of Duchenne muscular dystrophy (DMD) are needed, especially in the context of clinical trials. We report changes in muscle magnetic resonance imaging (MRI) parameters in participants with DMD, including changes in lean muscle volume (LMV), muscle fat fraction (MFF), and muscle fat infiltration (MFI) and their relationship to changes in functional parameters.
Methods MRI data were obtained...
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