Combination of scavenger receptor-A with anti-cyclic citrullinated peptide antibody for the diagnosis of rheumatoid arthritis

  • Published on 06/07/2024
  •  Reading time: 4 min.

Chaonan Wei, 1, Ping Wang, 1, Jian Zhang, 1, Xiang Jiang, 1, Yang Xie, 1, Yingni Li, 1, Wei Zhang, 2, Yan Du, 3, Xi Zheng, 1,4, Xiangyu Fang, 1, Shuyan Liu, 1, Lulu Cao, 1, Ranran Yao, 1, Xu Jin, 1,4, Danxue Zhu, 1,4, Huaxiang Wu, 3, Yongfu Wang, 2, Zhanguo Li, 1,4,5, Fanlei Hu 1,5,6

1 Department of Rheumatology and Immunology, Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Beijing, China
2 Department of Rheumatology and Immunology, First Hospital Affiliated to Baotou Medical College & Inner Mongolia Key Laboratory of Autoimmunity, Baotou, China
3 Department of Rheumatology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
4 Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China
5 State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China
6 Department of Integration of Chinese and Western Medicine, School of Basic Medical Sciences, Peking University, Beijing, China

Correspondence: Department of Rheumatology and Immunology, Peking University People’s Hospital, 11 Xizhimen South Street, Beijing 100044, China. E-mail addresses: fanleihu@bjmu.edu.cn (F. Hu)

Abstract

Objectives The routine biomarkers for rheumatoid arthritis (RA), including anticyclic citrullinated peptide antibody (anti-CCP), rheumatoid factor (RF), immunoglobulin M (IgM), erythrocyte sedimentation rate (ESR), and C-reaction protein (CRP) have limited sensitivity and specificity. Scavenger receptor-A (SR-A) is a novel RA biomarker identified by our group recently, especially for seronegative RA. Here, we performed a large-scale multicentre study to further assess...

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