Metformin treatment reduces the incidence of osteoporosis: a two-sample Mendelian randomized study

  • Published on 06/07/2024
  •  Reading time: 6 min.

Cai Yaotian , Jun Gao , Zhuang Xiaojie Changzhou Traditional Chinese Medical Hospital Affiliated to Nanjing University of Traditional Chinese Medicine 25 North Heping Road 213000 Changzhou Jiangsu China


Summary It remains unclear whether the association between metformin and osteoporosis (OP) risk is causal. This two-sample Mendelian randomization (MR) study suggests a causal relationship between metformin treatment and a decrease in OP and fracture incidence, as well as an increase in bone mineral density (BMD) in the lumbar spine, femoral neck, and heel. Nonetheless, no significant causal effect is observed on forearm BMD.
Purpose We utilize a MR approach...


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