Plasma biomarkers of Alzheimer´s disease in the continuum of dementia with Lewy bodies

  • Published on 07/02/2024
  •  Reading time: 4 min.

Patricia Diaz‐Galvan 1, Scott A. Przybelski 2, Alicia Algeciras‐Schimnich 1, Timothy G. Lesnick 2, Christopher G. Schwarz 1, Matthew L. Senjem 1, Jeffrey L. Gunter 1, Clifford R. Jack Jr. 1, Paul H Min 3, Manoj K. Jain 4, Toji Miyagawa 1, Leah K. Forsberg 1, Julie A. Fields 1, Rodolfo Savica 1, Jonathan Graff‐Radford 1, Vijay K Ramanan 1, David T. Jones 1, Hugo Botha 1, Erik K St Louis 1, David S. Knopman 1, Neill R Graff‐Radford 4, Tanis J Ferman 4, Ronald C. Petersen 1, Val J. Lowe 3, Brad F. Boeve 1, Kejal Kantarci 3

1 Mayo Clinic, Rochester, MN USA
2 Mayo Clinic, Quantitative Health Sciences, Rochester, MN USA
3 Mayo Clinic, Radiology, Rochester, MN USA
4 Mayo Clinic, Jacksonville, FL USA

Abstract

Background Patients with dementia with Lewy bodies (DLB) may have Alzheimer´s disease (AD) pathology. Plasma biomarkers of beta‐amyloid (Aß), phosphorylated tau (pTau), and neurodegeneration are sensitive to AD neuropathologic changes in AD dementia. While these plasma biomarkers are well tested in the AD continuum, their performance for concomitant AD pathology in the DLB continuum is still unclear.
Method We included patients with isolated...

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