Deciphering the Power of Resveratrol in Mitophagy: From Molecular Mechanisms to Therapeutic Applications
- Published on 05/09/2025
- Reading time: 13 min.
Hongmei Liu 1, Yixuan Song 2, Huan Wang 2, Ying Zhou 2, Min Xu 1, Jiaxun Xian 3
1
Department of Pharmacy
Affiliated Hospital of Southwest Jiaotong University, The Third People's Hospital of Chengdu
Chengdu
Sichuan
China
2
School of Pharmacy
Chengdu University of Traditional Chinese Medicine
Chengdu
China
3
Traditional Chinese Medicine Hospital of Meishan
Meishan
China
Abstract
Resveratrol (RES), a natural polyphenolic compound, has garnered significant attention for its therapeutic potential in various pathological conditions. This review explores how RES modulates mitophagy—the selective autophagic degradation of mitochondria essential for maintaining cellular homeostasis. RES promotes the initiation and execution of mitophagy by enhancing PINK1/Parkin‐mediated mitochondrial clearance, reducing reactive oxygen species production, and mitigating...
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