Multi-modal molecular determinants of clinically relevant osteoporosis subtypes

  • Published on 03/29/2024
  •  Reading time: 13 min.

Yuan Chunchun 1,2,3, Yu Xiang-Tian 4, Wang Jing 1,2,5, Shu Bing 2,6, Wang Xiao-Yun 7, Huang Chen 1,2,3, Lv Xia 8, Peng Qian-Qian 9, Qi Wen-Hao 10,11, Zhang Jing 12, Zheng Yan 10,11, Wang Si-Jia 9, Liang Qian-Qian 1,2,3, Shi Qi 1,2,3,6, Li Ting 9, Huang He 9,10, Mei Zhen-Dong 10,11, Zhang Hai-Tao 1,2,3, Xu Hong-Bin 1,2,3, Cui Jiarui 1,2,3, Wang Hongyu 1,2,3, Zhang Hong 1,2,3, Shi Bin-Hao 1,2,3, Sun Pan 1,2,3, Zhang Hui 8, Ma Zhao-Long 8, Feng Yuan 12, Chen Luonan 13, Zeng Tao 14, Tang De-Zhi 1,2,3, Wang Yong-Jun 1,2,3,6

1 Longhua Hospital Shanghai University of Traditional Chinese Medicine Shanghai China
2 Key Laboratory of Theory and Therapy of Muscles and Bones Ministry of Education Shanghai China
3 Spine Institute Shanghai Academy of Traditional Chinese Medicine Shanghai China
4 Clinical Research Center Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China
5 Shanghai Geriatric Institute of Chinese Medicine Shanghai China
6 Shanghai University of Traditional Chinese Medicine Shanghai China
7 Shanghai Research Institute of Acupuncture and Meridian Shanghai China
8 Hudong Hospital of Shanghai Shanghai China
9 CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health University of Chinese Academy of Sciences, Chinese Academy of Sciences Shanghai China
10 Ministry of Education Key Laboratory of Contemporary Anthropology, Department of Anthropology and Human Genetics, School of Life Science Fudan University Shanghai China
11 State Key Laboratory of Genetic Engineering, School of Life Sciences and Human Phenome Institute Fudan University Shanghai China
12 Green Valley (Shanghai) Pharmaceuticals Co., Ltd. Shanghai China
13 State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences University of Chinese Academy of Sciences Shanghai China
14 Guangzhou National Laboratory Guangzhou China


Due to a rapidly aging global population, osteoporosis and the associated risk of bone fractures have become a wide-spread public health problem. However, osteoporosis is very heterogeneous, and the existing standard diagnostic measure is not sufficient to accurately identify all patients at risk of osteoporotic fractures and to guide therapy. Here, we constructed the first prospective multi-omics atlas of the largest osteoporosis cohort to date (longitudinal data from 366 participants...


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