CD19 Chimeric Antigen Receptor T Cell Treatment: Unraveling the Role of B Cells in Systemic Lupus Erythematosus

  • Published on 09/02/2024
  •  Reading time: 4 min.

Jule Taubmann , Fabian Müller , Melek Yalcin Mutlu , Simon Völkl , Michael Aigner , Aline Bozec , Andreas Mackensen , Ricardo Grieshaber‐Bouyer , Georg Schett

Friedrich‐Alexander‐Universität Erlangen Nürnberg and Universitätsklinikum Erlangen Erlangen Germany

Abstract

B cell generation of autoantibodies is a crucial step in the pathogenesis of systemic lupus erythematosus (SLE). After their differentiation in the bone marrow, B cells populate the secondary lymphatic organs, where they undergo further maturation leading to the development of memory B cells as well as antibody‐producing plasmablasts and plasma cells. Targeting B cells is an important strategy to treat autoimmune diseases such as SLE, in which B cell tolerance is disturbed...

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