Muscle diffusion tensor imaging in facioscapulohumeral muscular dystrophy

  • Published on 07/05/2024
  •  Reading time: 4 min.

Leonardo Barzaghi MSc 1,2,3, Matteo Paoletti MD 2, Mauro Monforte MD 4, Sara Bortolani MD 4, Chiara Bonizzoni 2, Feiweier Thorsten PhD 5, Niels Bergsland PhD 6,7, Francesco Santini PhD 8,9, Xeni Deligianni PhD 8,9, Giorgio Tasca MD 4,10, Elena Ballante PhD 11,12, Silvia Figini PhD 11,12, Enzo Ricci MD 4, Anna Pichiecchio MD 2,13

1 Department of Mathematics University of Pavia Pavia Italy
2 Advanced Imaging and Artificial Intelligence Center, Neuroradiology Department IRCCS Mondino Foundation Pavia Italy
3 INFN, Group of Pavia Pavia Italy
4 UOC di Neurologia, Fondazione Policlinico Universitario A. Gemelli IRCCS Rome Italy
5 Siemens Healthcare GmbH Erlangen Germany
6 Department of Neurology Jacobs School of Medicine and Biomedical Sciences, Buffalo Neuroimaging Analysis Center, University of Buffalo, The State University of New York Buffalo New York USA
7 IRCCS, Fondazione Don Carlo Gnocchi ONLUS Milan Italy
8 Department of Radiology University Hospital Basel Basel Switzerland
9 Basel Muscle MRI, Department of Biomedical Engineering University of Basel Basel Switzerland
10 John Walton Muscular Dystrophy Research Centre, Newcastle University and Newcastle Hospitals NHS Foundation Trusts Newcastle upon Tyne UK
11 Department of Political and Social Sciences University of Pavia Pavia Italy
12 BioData Science Center, IRCCS Mondino Foundation Pavia Italy
13 Department of Brain and Behavioral Sciences University of Pavia Pavia Italy


Introduction/Aims Muscle diffusion tensor imaging has not yet been explored in facioscapulohumeral muscular dystrophy (FSHD). We assessed diffusivity parameters in FSHD subjects compared with healthy controls (HCs), with regard to their ability to precede any fat replacement or edema.
Methods Fat fraction (FF), water T2 (wT2), mean, radial, axial diffusivity (MD, RD, AD), and fractional anisotropy (FA) of thigh muscles were calculated in 10 FSHD subjects...


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