Muscle diffusion tensor imaging in facioscapulohumeral muscular dystrophy
- Published on 07/05/2024
- Reading time: 4 min.
Leonardo Barzaghi MSc 1,2,3, Matteo Paoletti MD 2, Mauro Monforte MD 4, Sara Bortolani MD 4, Chiara Bonizzoni 2, Feiweier Thorsten PhD 5, Niels Bergsland PhD 6,7, Francesco Santini PhD 8,9, Xeni Deligianni PhD 8,9, Giorgio Tasca MD 4,10, Elena Ballante PhD 11,12, Silvia Figini PhD 11,12, Enzo Ricci MD 4, Anna Pichiecchio MD 2,13
1
Department of Mathematics
University of Pavia
Pavia
Italy
2
Advanced Imaging and Artificial Intelligence Center, Neuroradiology Department
IRCCS Mondino Foundation
Pavia
Italy
3
INFN, Group of Pavia
Pavia
Italy
4
UOC di Neurologia, Fondazione Policlinico Universitario A. Gemelli IRCCS
Rome
Italy
5
Siemens Healthcare GmbH
Erlangen
Germany
6
Department of Neurology
Jacobs School of Medicine and Biomedical Sciences, Buffalo Neuroimaging Analysis Center, University of Buffalo, The State University of New York
Buffalo
New York
USA
7
IRCCS, Fondazione Don Carlo Gnocchi ONLUS
Milan
Italy
8
Department of Radiology
University Hospital Basel
Basel
Switzerland
9
Basel Muscle MRI, Department of Biomedical Engineering
University of Basel
Basel
Switzerland
10
John Walton Muscular Dystrophy Research Centre, Newcastle University and Newcastle Hospitals NHS Foundation Trusts
Newcastle upon Tyne
UK
11
Department of Political and Social Sciences
University of Pavia
Pavia
Italy
12
BioData Science Center, IRCCS Mondino Foundation
Pavia
Italy
13
Department of Brain and Behavioral Sciences
University of Pavia
Pavia
Italy
Abstract
Introduction/Aims Muscle diffusion tensor imaging has not yet been explored in facioscapulohumeral muscular dystrophy (FSHD). We assessed diffusivity parameters in FSHD subjects compared with healthy controls (HCs), with regard to their ability to precede any fat replacement or edema.
Methods Fat fraction (FF), water T2 (wT2), mean, radial, axial diffusivity (MD, RD, AD), and fractional anisotropy (FA) of thigh muscles were calculated in 10 FSHD subjects...
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