Clinical and immunological biomarkers can identify proliferative changes and predict renal flares in lupus nephritis
- Published on 04/11/2025
- Reading time: 5 min.
Calatroni Marta 1,2, Conte Emanuele 2,3, Stella Matteo 2, De Liso Federica 4, Reggiani Francesco 1,2, Moroni Gabriella 1,2
1 https://ror.org/020dggs04 Department of Biomedical Sciences Humanitas University Via Rita Levi Montalcini 4, Pieve Emanuele 20072 Milan Italy
2 https://ror.org/05d538656 Nephrological Unit, Nephrology and Dialysis Division IRCCS Humanitas Research Hospital Via Manzoni 56, Rozzano 20089 Milan Italy
3 https://ror.org/01ynf4891 School of Specialization in Nephrology University of Milano Bicocca, ASST Monza Monza Italy
4 https://ror.org/016zn0y21 Clinical Pathology Unit Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico Milan Italy
Abstract
Background Kidney involvement is frequent in SLE, with proliferative lupus nephritis (LN) forms and nephritic flares being key predictors of poor outcomes. Conflicting results have been reported for anti-C1q antibodies among the serological markers. Our purpose was to assess the value of immunological tests (C3,C4 complement fractions, anti-DNA and antiC1q antibodies) in predicting histological classes and flares of lupus nephritis (LN).
Methods For histological...
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