Comparison of different intervention thresholds for the treatment of glucocorticoid-induced osteoporosis: a cross-sectional study

  • Published on 04/11/2025
  •  Reading time: 4 min.

Puksun Kanchalee 1, Pongchaiyakul Chatlert 2, Pakchotanon Rattapol 1, Narongroeknawin Pongthorn 1, Leosuthamas Pornsawan 1, Arunthanachaikul Thunyawarin 1, Chaiamnuay Sumapa 1

1 https://ror.org/007h1qz76 Rheumatic Disease Unit, Department of Internal Medicine Phramongkutklao Hospital and College of Medicine 315 Rajavithi road, Rajathevee district 10400 Bangkok Thailand
2 https://ror.org/03cq4gr50 Division of Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine Khon Kaen University Khon Kaen Thailand

Abstract

Background Glucocorticoid-induced osteoporosis (GIO) is the most common drug-induced osteoporosis. Early detection and treatment may decrease the fragility fractures. Several GIO guidelines exist, although they vary in recommended intervention thresholds for initiating pharmacologic treatment. This study aimed to evaluate the performance of intervention thresholds in treating GIO under various guidelines.
Methods Rheumatic disease patients receiving ≥ 2.5 mg/day...

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