Functions of Epimedin C in a zebrafish model of glucocorticoid‐induced osteoporosis
- Published on 08/30/2024
- Reading time: 6 min.
Xiaoyang Zhou 1,2, Kai Lian 1, Junjie Jia 1, Xue Zhao 2, Peng Duan 2, Jiaolong Huang 2, Yihua Shi 1
1
Department of Orthopedics, Xiangyang No. 1 People's Hospital
Hubei University of Medicine
Xiangyang
China
2
Key Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases of Xiangyang City, Department of Obstetrics and Gynaecology, Xiangyang No. 1 People's Hospital
Hubei University of Medicine
Xiangyang
China
Abstract
Epimedium is thought to enhance the integrity of tendons and bones, ease joint discomfort and rigidity and enhance kidney function. Although glucocorticoids are commonly used in clinical practice, the mechanism by which the active compound Epimedin C (EC) alleviates glucocorticoid‐induced osteoporosis (GIOP) is not well understood. The therapeutic potential of EC in treating GIOP was evaluated using alizarin red S staining, calcein immersion and fluorescence imaging, and...
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