Association of homocysteine with white matter dysconnectivity in schizophrenia
- Published on 04/02/2024
- Reading time: 5 min.
Tabata Koichi 1,2, Son Shuraku 3, Miyata Jun 3, Toriumi Kazuya 1, Miyashita Mitsuhiro 4, Suzuki Kazuhiro 1,5, Itokawa Masanari 1,6, Takahashi Hidehiko 2,7, Murai Toshiya 3, Arai Makoto 1
1 https://ror.org/00vya8493 Schizophrenia Research Project, Department of Psychiatry and Behavioral Sciences Tokyo Metropolitan Institute of Medical Science Tokyo Japan
2 https://ror.org/051k3eh31 Department of Psychiatry and Behavioral Sciences, Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University Tokyo Japan
3 https://ror.org/02kpeqv85 Department of Psychiatry, Graduate School of Medicine Kyoto University Kyoto Japan
4 https://ror.org/00vya8493 Unit for Mental Health Promotion, Research Center for Social Science & Medicine Tokyo Metropolitan Institute of Medical Science Tokyo Japan
5 https://ror.org/0244rem06 Department of Psychiatry Shinshu University School of Medicine Matsumoto Japan
6 https://ror.org/037yff262 Department of Psychiatry Tokyo Metropolitan Matsuzawa Hospital Tokyo Japan
7 https://ror.org/051k3eh31 Center for Brain Integration Research Tokyo Medical and Dental University Tokyo Japan
Abstract
Several studies have shown white matter (WM) dysconnectivity in people with schizophrenia (SZ). However, the underlying mechanism remains unclear. We investigated the relationship between plasma homocysteine (Hcy) levels and WM microstructure in people with SZ using diffusion tensor imaging (DTI). Fifty-three people with SZ and 83 healthy controls (HC) were included in this retrospective observational study. Tract-Based Spatial Statistics (TBSS) were used to evaluate group differences...
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