Neutrophils in Atopic Dermatitis

  • Published on 01/06/2025
  •  Reading time: 17 min.

Chih-Chao Chiang 1 ,2  na1, Wei-Jen Cheng 3 ,4  na1, Tsong-Long Hwang 5 ,9 ,10 ,11  

1 Department of Nutrition and Health Sciences, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan
2 Puxin Fengze Chinese Medicine Clinic, Taoyuan, Taiwan
3 School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan
4 Center for Traditional Chinese Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan
5 Graduate Institute of Health Industry Technology and Research Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan
9 Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan, Taiwan
10 Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan, Taiwan
11 Department of Chemical Engineering, Ming Chi University of Technology, New Taipei City, Taiwan

Abstract

Neutrophils have a critical role in inflammation. Recent studies have identified their distinctive presence in certain types of atopic dermatitis (AD), yet their exact function remains unclear. This review aims to compile studies elucidating the role of neutrophils in AD pathophysiology. Proteins released by neutrophils, including myeloperoxidase, elastase, and lipocalin, contribute to pruritus progression in AD. Neutrophilic oxidative stress and the formation of neutrophil extracellular...

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