Aortic Valve Thrombus, Stroke, and Endovascular Thrombectomy in a Child With APML and Trisomy 21

  • Published on 07/10/2024
  •  Reading time: 2 min.

Plant, Gayathri MD, MPH*; Kirton, Adam MD, MSc+; Guilcher, Gregory M.T. MD++,[S],[//]; AlNajjar, Mohammad MD[S]; Mah, Kandice MD[P]; Mitha, Alim P. MD, SM, MSc#; Riva-Cambrin, Jay MD, MSc#; Steele, MacGregor MD**


APML, a subtype of acute myeloid leukemia, is highly curable, with cure rates over 90%. Despite its therapeutic success, APML poses elevated bleeding risks due to frequent prior disseminated intravascular coagulation. Less commonly recognized but critical is the thrombotic risk. We document a unique pediatric case: a 13-year-old with trisomy 21 diagnosed with APML had an asymptomatic aortic valve thrombus...


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