Gut microbiome and metabolism alterations in schizophrenia with metabolic syndrome severity

  • Published on 07/30/2024
  •  Reading time: 6 min.

Zhao Hongxia 1,2, Zhu Guang 3, Zhu Tong 1,4, Ding Binbin 3, Xu Ahong 3, Gao Songyan 5, Chao Yufan 1, Li Na 1, Chen Yongchun 6, Wang Zuowei 3,7, Jie Yong 3,7, Dong Xin 1,7

1 https://ror.org/006teas31 School of Medicine Shanghai University 200444 Shanghai China
2 https://ror.org/00zzrkp92 Zhanjiang Institute of Clinical Medicine, Central People’s Hospital of Zhanjiang 524045 Zhanjiang China
3 Hongkou Mental Health Center 200083 Shanghai China
4 https://ror.org/006teas31 School of Life Sciences Shanghai University 200444 Shanghai China
5 https://ror.org/006teas31 Institute of Translational Medicine Shanghai University 200444 Shanghai China
6 Department of Pharmacy, The First Naval Hospital of Southern Theater Command 524000 Zhanjiang China
7 https://ror.org/006teas31 Clinical Research Center for Mental Health, School of Medicine Shanghai University 200083 Shanghai China

Abstract

Background Schizophrenia (SCZ) patients undergoing antipsychotic treatment demonstrated a high prevalence and harmful effects of metabolic syndrome (MetS), which acted as the major cause of cardiovascular disease. The major clinical challenge is the lack of biomarkers to identify MetS episodes and prevent further damage, while the mechanisms underlying these drug-induced MetS remain unknown.
Methods This study divided 173 participants with SCZ into 3 groups...

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