Cellulite & Skin Tightening: A Review of Pathophysiology and Topical Treatment

  • Published on 03/10/2025
  •  Reading time: 5 min.

Isabella Castellanos‐García 1, Luisa Valentina Ramírez‐Zuluaga 1, Laura Sofia Páez‐Cárdenas 1, Dennys Lintsay Villalba‐Moreno 1, María Daniela Caicedo‐León 1, Elisha Singer 2, Thais Pincelli 1,2, Alison J. Bruce 2, Miguel A. Aristizabal 1,2

1 Research Division ADEI, Aesthetics & Dermatology Institute Bogota Colombia
2 Department of Dermatology Mayo Clinic Florida Jacksonville Florida USA

Abstract

Background Cellulite is a localized skin condition that affects many women, particularly after puberty. It results from a complex interplay of several factors that lead to the characteristic dimpled appearance of the skin. Cellulite may cause psychological stress and negatively impact quality of life. Additionally, body skin laxity may further exacerbate cosmetic concerns in these patients. Consequently, multiple therapeutic options, including topical treatments, have...

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