Epidemiological changes of invasive fungal disease in children with cancer: Prospective study of the National Child Program of Antineoplastic Drugs network, Chile

  • Published on 09/04/2024
  •  Reading time: 4 min.

Marlon Barraza 1, Romina Valenzuela 2, Milena Villarroel 2, Verónica de la Maza 2, Verónica Contardo 3,4, Ana María Álvarez 4,5, Valentina Gutiérrez 4,6, Marcela Zubieta 4,7, Daniela Martínez 4,8, María E. Santolaya 2,4

1 Department of Clinical Pharmacy Hospital Dr. Luis Calvo Mackenna Santiago Chile
2 Department of Pediatrics, Faculty of Medicine, Hospital Dr. Luis Calvo Mackenna Universidad de Chile Santiago Chile
3 Department of Pediatrics, Faculty of Medicine, Hospital Dr. Roberto del Río Universidad de Chile Santiago Chile
4 Committee of Infectious Diseases National Child Program of Antineoplastic Drugs (PINDA) Santiago Chile
5 Department of Pediatrics Hospital San Juan de Dios Santiago Chile
6 Department of Pediatrics, Faculty of Medicine, Hospital Dr. Sótero del Río Pontificia Universidad Católica Santiago Chile
7 Department of Pediatrics Hospital Dr. Exequiel González Cortés Santiago Chile
8 Department of Pediatrics, Faculty of Medicine, Hospital San Borja Arriarán Universidad de Chile Santiago Chile

Abstract

Background Invasive fungal diseases (IFD) are high morbidity and mortality infections in children with cancer suffering episodes of high‐risk febrile neutropenia (HRFN). IFD epidemiology has changed in the last two decades, with an increasing incidence in recent years due to the growing number of immunocompromised children at risk for IFD. The aim of this study was to evaluate the incidence of IFD in children with cancer in the period 2016–2020 compared...

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