Copy number deletion of PLA2G4A affects the susceptibility and clinical phenotypes of schizophrenia

  • Published on 06/11/2024
  •  Reading time: 6 min.

Gao Zibo , Guo Xinru , Sun Zhouyang , Wu Songyu , Wang Qianyi , Huang Qianlong , Bai Wei , Kou Changgui Department of Epidemiology and Biostatistics, School of Public Health Jilin University Changchun Jilin China


Phospholipase A2(PLA2) superfamily is recognized as being involved in the pathogenesis of schizophrenia by affecting lipid homeostasis in cell membranes. We hypothesized that PLA2 gene copy number variation (CNV) may affect PLA2 enzyme expression and be associated with schizophrenia risk. This study indicated that in the discovery stage, an increased copy number of PLA2G6 and the deletion of PLA2G3, PLA2G4A, PLA2G4F and PLA2G12F was associated with increased risk of schizophrenia....


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