Valacyclovir for the prevention of cytomegalovirus infection after kidney transplantation
- Published on 03/12/2025
- Reading time: 6 min.
Kim Jin Sug 1, Lee Na Rae 2, Park Kyun-Ik 2, Hwang Hyeon Seok 1, Lee Sang Ho 3, Chung Byung Ha 4, Jung Cheol Woong 5, Cho Jang-Hee 6, Park Woo Yeong 7, Kim Hyo Jin 8, Jeong Jong Cheol 9, Yang Jaeseok 10, Lee Yu Ho 11, Park Jae Berm 12, Jeon Jin Seok 13, Lee Juhan 14, Kim Yeong Hoon 15, Choi Soo Jin Na 16, Oh Jieun 17, Yoon Hye Eun 18, Kim Deok Gie 19, Shin Ho Sik 20,21, Ban Tae Hyun 22, Kim Myoung Soo 14, Ko Min Jung 2, Jeong Kyung Hwan 1, KOTRY study group
1 https://ror.org/01zqcg218 Division of Nephrology, Department of Internal Medicine Kyung Hee University College of Medicine, Kyung Hee University Medical Center 26, Kyungheedae-Ro, Dongdaemun-Gu 02447 Seoul Republic of Korea
2 https://ror.org/04f097438 Division of Healthcare Technology Assessment Research National Evidence-Based Healthcare Collaborating Agency 400, Neungdong-Ro, Gwangjin-Gu 04933 Seoul Republic of Korea
3 https://ror.org/05x9xyq11 Division of Nephrology, Department of Internal Medicine Kyung Hee University College of Medicine, Kyung Hee University Hospital at Gangdong Seoul Republic of Korea
4 https://ror.org/056cn0e37 Division of Nephrology, Department of Internal Medicine Seoul St. Mary’S Hospital Seoul Republic of Korea
5 https://ror.org/02cs2sd33 Department of Surgery Korea University Anam Hospital Seoul Republic of Korea
6 https://ror.org/04qn0xg47 Department of Internal Medicine, School of Medicine Kyungpook National University Hospital Daegu Republic of Korea
7 https://ror.org/00tjv0s33 Division of Nephrology, Department of Internal Medicine Keimyung University School of Medicine, Keimyung University Dongsan Hospital Daegu Republic of Korea
8 https://ror.org/01an57a31 Division of Nephrology, Department of Internal Medicine Pusan National University Hospital, Pusan National University School of Medicine Busan Republic of Korea
9 https://ror.org/00cb3km46 Division of Nephrology Seoul National University Bundang Hospital Seongnam Republic of Korea
10 https://ror.org/044kjp413 Division of Nephrology, Department of Internal Medicine Yonsei University College of Medicine, Severance Hospital Seoul Republic of Korea
11 https://ror.org/04yka3j04 Division of Nephrology, Department of Internal Medicine CHA Bundang Medical Center, CHA University Seongnam Republic of Korea
12 https://ror.org/05a15z872 Department of Surgery Samsung Medical Center, Sungkyunkwan University School of Medicine Seoul Republic of Korea
13 https://ror.org/05eqxpf83 Department of Internal Medicine Soonchunhyang University Seoul Hospital Seoul Republic of Korea
14 https://ror.org/01wjejq96 Department of Surgery Yonsei University College of Medicine Seoul Republic of Korea
15 https://ror.org/01pzf6r50 Department of Internal Medicine Inje University Busan Paik Hospital Busan Republic of Korea
16 https://ror.org/05kzjxq56 Department of Surgery Chonnam National University Medical School Gwangju Republic of Korea
17 https://ror.org/05mx1gf76 Department of Internal Medicine Kangdong Sacred Heart Hospital, Hallym University College of Medicine Seoul Republic of Korea
18 https://ror.org/017gxrm85 Division of Nephrology, Department of Internal Medicine Incheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea Incheon Republic of Korea
19 https://ror.org/01b346b72 Department of Surgery Yonsei University Wonju College of Medicine, Wonju Severance Christian Hospital Wonju Republic of Korea
20 https://ror.org/02xkmx604 Renal Division, Department of Internal Medicine Gospel Hospital, Kosin University College of Medicine Busan South Korea
21 https://ror.org/024b57v39 Transplantation Research Institute, Kosin University College of Medicine Busan South Korea
22 https://ror.org/01fpnj063 Division of Nephrology, Department of Internal Medicine Eunpyeong St. Mary’s Hospital, College of Medicine, The Catholic University of Korea Seoul Republic of Korea
Abstract
Background Cytomegalovirus (CMV) infection is a frequent complication after kidney transplantation (KT) and has various effects on recipient and graft survival. Although guidelines recommend anti-viral prophylaxis with ganciclovir or valganciclovir, there is a demand for alternative regimen for CMV prevention. We investigated the effects of a 3-month valacyclovir-based prophylaxis on CMV infection and clinical outcomes in KT recipients using a nationwide cohort.
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