Gain of bipolar disorder-related lncRNA AP1AR-DT in mice induces depressive and anxiety-like behaviors by reducing Negr1-mediated excitatory synaptic transmission
- Published on 01/07/2025
- Reading time: 10 min.
Li Shufen 1,2, Ni Hongyu 1,2, Wang Yaping 2, Wu Xiaohui 1,2, Bi Jianqiang 3, Ou Haiyan 1, Li Zhongwei 1, Ping Junjiao 4, Wang Zhongju 1, Chen Renhao 1, Yang Qiong 5, Jiang Meijun 6, Cao Liping 5, Jiang Tingyun 4, Ren Siqiang 2, Zhao Cunyou 1,2,7
1 Department of Medical Genetics, Guangdong Technology and Engineering Research Center for Molecular Diagnostics of Human Genetic Diseases, and Guangdong Engineering and Technology Research Center for Genetic Testing, School of Basic Medical Sciences, and Guangdong Mental Health Center, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Science) Southern Medical University Guangzhou China
2 https://ror.org/01vjw4z39 Key Laboratory of Mental Health of the Ministry of Education, Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Guangdong-Hong Kong Joint Laboratory for Psychiatric Disorders, Guangdong Province Key Laboratory of Psychiatric Disorders, and Guangdong Basic Research Center of Excellence for Integrated Traditional and Western Medicine for Qingzhi Diseases Southern Medical University, Guangzhou Guangzhou China
3 https://ror.org/02skpkw64 Shenzhen Kangning Hospital, Shenzhen Mental Health Center Shenzhen China
4 The Third People’s Hospital of Zhongshan Zhongshan Guangdong China
5 https://ror.org/00zat6v61 Department of Psychiatry The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital) Guangzhou China
6 https://ror.org/045kpgw45 Guangdong Mental Health Center, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Science) Guangzhou China
7 https://ror.org/01vjw4z39 Experimental Education/Administration Center, School of Basic Medical Science Southern Medical University Guangzhou China
Abstract
Background Bipolar disorder is a complex polygenic disorder that is characterized by recurrent episodes of depression and mania, the heterogeneity of which is likely complicated by epigenetic modifications that remain to be elucidated.
Methods We performed transcriptomic analysis of peripheral blood RNA from monozygotic (MZ) twins discordant for bipolar disorder to identify disease-associated differentially expressed long noncoding RNAs (DE-lncRNAs), which...
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