Abnormal expression of miR-3653-3p, caspase 1, IL-1β in peripheral blood of schizophrenia
- Published on 14/11/2023
- Reading time: 4 min.
Zhao Xin-ling 1, Liu Yi-lin 1, Long Qing 1, Zhang Yun-qiao 2, You Xu 2, Guo Ze-yi 1, Cao Xiang 1, Yu Lei 1, Qin Fu-yi 1, Teng Zhao-wei 3, Zeng Yong 1
1 Department of Psychiatry The Second Affiliated Hospital of Kunming Medical University Kunming Yunnan Province China
2 Psychiatric Ward Honghe Second People’s Hospital Honghe Yunnan Province China
3 Central Laboratory of the Second Affiliated Hospital of Kunming Medical University Kunming Yunnan Province China
Abstract
Schizophrenia (SCZ) is a chronic, highly relapsing, severe mental disorder with an unclear etiology. Cytokine-mediated neuroimmune abnormalities have been repeatedly revealed. IL-1β was reported to play a vital role in expanding the inflammatory response. However, the underlying molecular mechanism is poorly understood. In this study, we found that miR-3653-3p with the NLRP3 binding site in Targetscan was differentially expressed in miRNA high-throughput sequencing in schizophrenia...
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