Effects of Retinol, Natural Pea Peptide and Antioxidant Blend in a Topical Formulation: In Vitro and Clinical Evidence

  • Published on 03/10/2025
  •  Reading time: 5 min.

Brian Cook 1 , Melanie Riggs 1 , Edwin D. Lephart   2  

1 Nu Skin Global Research and Innovation, Nu Skin Enterprises, Provo, UT, USA
2 Department of Cell Biology and Physiology, The Neuroscience Center, College of Life Sciences, Brigham Young University, Provo, UT, 84602, USA

Abstract

Introduction Retinol has a long history of treating skin conditions, including photoaging. However, skin irritation with repeated use of retinol is well documented. The present study assessed the effectiveness of a novel topical formulation, referred to as retinol topical formulation (RTF), to improve the quality of skin health. The RTF was composed of a low dose retinol, a synthetic retinoid ester, a pea peptide, and an antioxidant blend.
Methods In vitro...

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