Sleep and circadian disruption in bipolar disorders: From psychopathology to digital phenotyping in clinical practice
- Published on 09/03/2024
- Reading time: 9 min.
André C. Tonon MD, PhD 1,2, Adile Nexha HBSc 2, Mariana Mendonça da Silva MD 3, Fabiano A. Gomes MD, PhD 1,2, Maria Paz Hidalgo MD, PhD 3,4, Benicio N. Frey MD, PhD 1,2
1
Mood Disorders Program and Women's Health Concerns Clinic, St. Joseph's Healthcare Hamilton
Hamilton
Ontario
Canada
2
Department of Psychiatry and Behavioural Neurosciences
McMaster University
Hamilton
Ontario
Canada
3
Laboratório de Cronobiologia e Sono
Porto Alegre Clinicas Hospital, Federal University of Rio Grande do Sul (UFRGS)
Porto Alegre
Brazil
4
Graduate Program in Psychiatry and Behavioral Sciences
Federal University of Rio Grande do Sul (UFRGS)
Porto Alegre
Brazil
Abstract
Sleep and biological rhythms are integral to mood regulation across the lifespan, particularly in bipolar disorder (BD), where alterations in sleep phase, structure, and duration occur in all mood states. These disruptions are linked to poorer quality of life, heightened suicide risk, impaired cognitive function, and increased relapse rates. This review highlights the pathophysiology of sleep disturbances in BD and aims to consolidate understanding and clinical applications of...
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