Associations of systemic inflammatory regulators with CKD and kidney function: evidence from the bidirectional mendelian randomization study

  • Published on 07/03/2024
  •  Reading time: 6 min.

Liu Hailang , Xiang Wei , Wu Wei , Zhou Gaofeng , Yuan Jingdong

Department of Urology, Wuhan Integrated TCM & Western Medicine Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan No.1 Hospital Wuhan China


Background Previous observational studies have reported that systemic inflammatory regulators are related to the development of chronic kidney disease (CKD); however, whether these associations are causal remains unclear. The current study aimed to investigate the potential causal relationships between systemic inflammatory regulators and CKD and kidney function.
Method We performed bidirectional two-sample Mendelian randomization (MR) analyses to infer...


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