Epstein–Barr Virus‐Associated Smooth Muscle Tumor After Kidney Transplantation: A French Multicenter Retrospective Study

  • Published on 05/07/2025
  •  Reading time: 4 min.

Laurène Tardieu1, Dany Anglicheau2, Rebecca Sberro‐Soussan2, Mathilde Lemoine3, Léonard Golbin4, Ophélie Fourdinier5, Julie Bruneau6, Marina Charbit7, Tchao Meatchi8, Jean‐Emmanuel Serre9, Moglie Le Quintrec9, Alexandre Karras1, Eric Thervet1, Hélène Lazareth 1

1 Service de Néphrologie et Hémodialyse Hôpital Européen Georges Pompidou, AP‐HP, Université Paris Cité Paris France
2 Service de Transplantation rénale Hôpital Universitaire Necker‐Enfants‐Malades, AP‐HP, Université Paris Cité Paris France
3 Service de Néphrologie CHU de Rouen Rouen France
4 Service de Néphrologie CHU de Rennes Rennes France
5 Service de Néphrologie et Transplantation rénale CHU d'Amiens Amiens France
6 Service d'Anatomopathologie Hôpital Universitaire Necker‐Enfants‐Malades, AP‐HP, Université Paris Cité Paris France
7 Service de Néphrologie Pédiatrique Hôpital Universitaire Necker‐Enfants‐Malades, AP‐HP, Université Paris Cité Paris France
8 Service d'Anatomopathologie Hôpital Européen Georges Pompidou, AP‐HP, Université Paris Cité Paris France
9 Service de Néphrologie Transplantation Université de Montpellier Montpellier France

Abstract

Background Epstein–Barr virus (EBV) is a herpesvirus linked to nine different human tumors and lymphoproliferative disorders. Immunosuppression promotes EBV‐driven malignancies. The most frequent EBV‐induced malignancies are lymphomas and nasopharyngeal carcinoma. By promoting smooth muscle proliferation, EBV can induce EBV‐associated smooth muscle tumors (EBV‐SMT). EBV‐SMT is a rare oncological entity for which no current guideline...

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