Integrated proteomic and genomic analysis to identify predictive biomarkers for valproate response in bipolar disorder: a 6-month follow-up study

  • Published on 06/11/2024
  •  Reading time: 5 min.

Lee Hyunju 1, Han Dohyun 2,3, Hong Kyung Sue 4,5, Ha Kyooseob 4,5, Kim Hyeyoon 2, Cho Eun Young 6, Myung Woojae 7,8, Rhee Sang Jin 9, Kim Jayoun 10, Ha Tae Hyon 7,8, Lee Kang Eun 9, Jung Hye Won 6, Lee Yejin 6, Lee Dongbin 12, Yu Hyeona 8, Lee Daseul 8, Park Yun Seong 8, Ahn Yong Min 1,7,11, Baek Ji Hyun 12, Kim Se Hyun 1

1 https://ror.org/01z4nnt86 Department of Neuropsychiatry Seoul National University Hospital 101, Daehak-Ro, Jongno-Gu 03080 Seoul Republic of Korea
2 https://ror.org/01z4nnt86 Proteomics Core Facility, Biomedical Research Institute Seoul National University Hospital Seoul Republic of Korea
3 https://ror.org/01z4nnt86 Transdisciplinary Department of Medicine & Advanced Technology Seoul National University Hospital Seoul Republic of Korea
4 https://ror.org/03rmrcq20 Department of Psychiatry University of British Columbia Vancouver BC Canada
5 https://ror.org/02pyp8h55 Department of Psychiatry Lions Gate Hospital - Vancouver Coastal Health British Columbia Canada
6 https://ror.org/05a15z872 Samsung Institute of Future Medicine Samsung Medical Center Seoul Republic of Korea
7 https://ror.org/04h9pn542 Department of Psychiatry Seoul National University College of Medicine Seoul Republic of Korea
8 https://ror.org/00cb3km46 Department of Neuropsychiatry Seoul National University Bundang Hospital Seongnam Republic of Korea
9 https://ror.org/01z4nnt86 Biomedical Research Institute Seoul National University Hospital Seoul Republic of Korea
10 https://ror.org/01z4nnt86 Medical Research Collaborating Center Seoul National University Hospital Seoul Republic of Korea
11 https://ror.org/04h9pn542 Institute of Human Behavioral Medicine Seoul National University Medical Research Center Seoul Republic of Korea
12 https://ror.org/05a15z872 Department of Psychiatry, Samsung Medical Center Sunkyunkwan University School of Medicine 115 Irwon-Ro, Gangnam-Gu 03080 Seoul Republic of Korea

Abstract

Background Several genetic studies have been undertaken to elucidate the intricate interplay between genetics and drug responses in bipolar disorder (BD). However, there has been notably limited research on biomarkers specifically linked to valproate, with only a few studies investigating integrated proteomic and genomic factors in response to valproate treatment. Therefore, this study aimed to identify biological markers for the therapeutic response to valproate treatment...

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