Epigenetics factors in schizophrenia: future directions for etiologic and therapeutic study approaches

  • Published on 04/15/2025
  •  Reading time: 6 min.

Yang Haidong 1,2, Sun Wenxi 2, Li Jin 2, Zhang Xiaobin 2

1 https://ror.org/059gcgy73 Department of Psychiatry The Fourth People’s Hospital of Lianyungang, The Affiliated KangDa College of Nanjing Medical University 222003 Lianyungang People’s Republic of China
2 https://ror.org/05t8y2r12 Institute of Mental Health Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow University 215137 Suzhou People’s Republic of China

Abstract

Schizophrenia is a complex, heterogeneous, and highly disabling severe mental disorder whose pathogenesis has not yet been fully elucidated. Epigenetics, as a bridge between genetic and environmental factors, plays an important role in the pathophysiology of schizophrenia. Over the past decade, epigenetic-wide association studies have rapidly become an important branch of psychiatric research, especially in deciphering the molecular mechanisms of schizophrenia. This review systematically...

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