Differences in corneal nerve fiber density and fiber length in patients with painful chronic idiopathic axonal polyneuropathy and diabetic polyneuropathy

  • Published on 07/31/2024
  •  Reading time: 5 min.

Mariska D. Nieuwenhoff MD 1,2, Hoang‐Ton Nguyen MD 3, Sjoerd P. Niehof PhD 1, Frank J. P. M. Huygen MD, PhD 1, Ajay Verma PhD 4, Erica S. Klaassen MSc 2, Malik Bechakra PhD 1, Wouter J. Geelhoed PhD 2, Joost L. M. Jongen MD, PhD 1,5, Annette C. Moll MD, PhD 3, Alexander F. J. E. Vrancken MD, PhD 6, Axel Petzold MD, PhD 3,7,8, Geert Jan Groeneveld MD, PhD 2,9

1 Department of Anesthesiology and Pain Medicine Erasmus MC University Medical Center Rotterdam The Netherlands
2 Centre for Human Drug Research Leiden The Netherlands
3 Department of Ophthalmology Amsterdam UMC location VU University Medical Center Amsterdam The Netherlands
4 Biogen Cambridge Massachusetts USA
5 Department of Neurology Erasmus MC University Medical Center Rotterdam The Netherlands
6 Department of Neurology, Brain Center Rudolf Magnus University Medical Center Utrecht Utrecht The Netherlands
7 Department of Neurology Amsterdam UMC location VU University Medical Center Amsterdam The Netherlands
8 Moorfields Eye Hospital The National Hospital for Neurology and Neurosurgery and the Queen Square Institute of Neurology, UCL London UK
9 Department of Anesthesiology Leiden University Medical Center Leiden The Netherlands
Formation Venture Engineering Foundry Boston Massachusetts USA

Abstract

Introduction/Aims Corneal confocal microscopy (CCM) detects small nerve fiber loss and correlates with skin biopsy findings in diabetic neuropathy. In chronic idiopathic axonal polyneuropathy (CIAP) this correlation is unknown. Therefore, we compared CCM and skin biopsy in patients with CIAP to healthy controls, patients with painful diabetic neuropathy (PDN) and diabetics without overt neuropathy (DM).
Methods Participants with CIAP and suspected small...

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