Differences in corneal nerve fiber density and fiber length in patients with painful chronic idiopathic axonal polyneuropathy and diabetic polyneuropathy
- Published on 07/31/2024
- Reading time: 5 min.
Mariska D. Nieuwenhoff MD 1,2, Hoang‐Ton Nguyen MD 3, Sjoerd P. Niehof PhD 1, Frank J. P. M. Huygen MD, PhD 1, Ajay Verma PhD 4, Erica S. Klaassen MSc 2, Malik Bechakra PhD 1, Wouter J. Geelhoed PhD 2, Joost L. M. Jongen MD, PhD 1,5, Annette C. Moll MD, PhD 3, Alexander F. J. E. Vrancken MD, PhD 6, Axel Petzold MD, PhD 3,7,8, Geert Jan Groeneveld MD, PhD 2,9
1
Department of Anesthesiology and Pain Medicine
Erasmus MC University Medical Center
Rotterdam
The Netherlands
2
Centre for Human Drug Research
Leiden
The Netherlands
3
Department of Ophthalmology
Amsterdam UMC location VU University Medical Center
Amsterdam
The Netherlands
4
Biogen
Cambridge
Massachusetts
USA
5
Department of Neurology
Erasmus MC University Medical Center
Rotterdam
The Netherlands
6
Department of Neurology, Brain Center Rudolf Magnus
University Medical Center Utrecht
Utrecht
The Netherlands
7
Department of Neurology
Amsterdam UMC location VU University Medical Center
Amsterdam
The Netherlands
8
Moorfields Eye Hospital
The National Hospital for Neurology and Neurosurgery and the Queen Square Institute of Neurology, UCL
London
UK
9
Department of Anesthesiology
Leiden University Medical Center
Leiden
The Netherlands
Formation Venture Engineering Foundry
Boston
Massachusetts
USA
Abstract
Introduction/Aims Corneal confocal microscopy (CCM) detects small nerve fiber loss and correlates with skin biopsy findings in diabetic neuropathy. In chronic idiopathic axonal polyneuropathy (CIAP) this correlation is unknown. Therefore, we compared CCM and skin biopsy in patients with CIAP to healthy controls, patients with painful diabetic neuropathy (PDN) and diabetics without overt neuropathy (DM).
Methods Participants with CIAP and suspected small...
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