Bacterial antigens and asthma: a comparative study of common respiratory pathogenic bacteria

  • Published on 04/02/2024
  •  Reading time: 4 min.

Jie Pang MSc a b # , Yifan Shi MSc a # , Dan Peng PhD a , Lele Cui PhD a , Yingjie Xu PhD a , Wenjing Wang PhD c , Yue Hu PhD a , Yiran Yang PhD a , Jingjing Wang MSc d , Xiaofeng Qin MSc a , Yue Zhang PhD e , Hao Meng MSc f , Dan Wang PhD a , Ge Bai MSc a , Huihui Yuan PhD a , Jie Liu MSc a , Zhe Lv PhD a , Yan Li PhD g , Ye Cui PhD a , Wenjun Wang PhD h , Kewu Huang MD h , Chris J Corrigan MD i , Wei Wang MD a , Yan Chen PhD a * & Sun Ying MD a *

a Department of Immunology, School of Basic Medical Sciences, Capital Medical University, Beijing, China
b The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China
c Beijing Youan Hospital, Capital Medical University, Beijing, China
d Department of Laboratory Animal Sciences, Capital Medical University, Beijing, China
e Fifth School of Clinical Medicine, Peking University, Beijing, China
f The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Medical School of Chinese PLA, Beijing, China
g Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing Institute of Otorhinolaryngology, Key Laboratory of Otorhinolaryngology Head and Neck Surgery, Ministry of Education, Beijing Key Laboratory of Nasal Diseases, Beijing, China
h Department of Respiratory and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University & Beijing Institute of Respiratory Medicine, Beijing, China
i Division of Asthma, Allergy & Lung Biology, MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, King's College London, London, UK

CONTACT Sun Ying ying.sun@ccmu.edu.cn
Yan Chen chenchen@ccmu.edu.cn Department of Immunology, School of Basic Medical Sciences, Capital Medical University, 10# Xi Tou Tiao, You An Men Wai, Fengtai District, Beijing, 100069, China.

Abstract

Objective In a previous study we have shown that, in the presence of interleukin (IL)-33, repeated, per-nasal challenge of murine airways with Streptococcus pneumoniae(S. pneumoniae) organisms induces human asthma-like airways inflammation. It is not clear, however, whether this effect is unique or manifest in response to other common respiratory pathogens.
Methods To explore this, airways of BALB/c mice were repeatedly challenged...

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