Diagnosis of in-hospital mortality using admission CT perfusion in severe traumatic brain injury patients (ACT-TBI study)
- Published on 05/07/2025
- Reading time: 5 min.
Shankar Jai 1, Alcock Susan 1, Leeies Murdoch 2, Ayroso Marco 1, Unrau Sarah 1, Park JaeYeon 1, Blackwood Benjamin 1, Trivedi Reva 1, Marin Roman 1, Raja Muhammed 1, Sinha Namita 3, Trivedi Anurag 4, Essig Marco 1, Martin Douglas 2, Grierson Robert 2, Zeiler Frederick A. 5,6,7,8
1 https://ror.org/02gfys938 Department of Radiology University of Manitoba Winnipeg MB Canada
2 https://ror.org/02gfys938 Department of Emergency Medicine University of Manitoba Winnipeg MB Canada
3 https://ror.org/02gfys938 Department of Pathology University of Manitoba Winnipeg MB Canada
4 https://ror.org/02gfys938 Department of Neurology University of Manitoba Winnipeg MB Canada
5 https://ror.org/02gfys938 Section of Neurosurgery, Department of Surgery, Rady Faculty of Health Sciences University of Manitoba Winnipeg MB Canada
6 https://ror.org/02gfys938 Department of Biomedical Engineering, Price Faculty of Engineering University of Manitoba Winnipeg MB Canada
7 https://ror.org/0168g2651 Pan Am Clinic Foundation Winnipeg MB Canada
8 https://ror.org/056d84691 Department of Clinical Neuroscience Karolinska Institutet Stockholm Sweden
Abstract
Background Severe traumatic brain injury (TBI) stands as the leading cause of post-injury hospitalization, disability, and mortality globally. Imaging serves as a cornerstone in the assessment of patients with severe TBI and CT Perfusion (CTP) has emerged as an early prognostic tool. Our study aims to validate CTP features of non-survivable brain injury, upon hospital admission to characterize in-hospital mortality, through a well-powered prospective cohort study.
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