Inhibition of S100A4 decreases neurotoxic astrocyte reactivity and attenuates neuropathic pain via the TLR4/NF-κB pathway in a rat model of spinal nerve ligation
- Published on 05/07/2025
- Reading time: 10 min.
Xue Tao 1, Song Yu 2, Zhao Jie 1, Fan Guiyong 3, Liu Zhiyuan 1,4,5
1 https://ror.org/03jc41j30 Department of Orthopedics Wujin Hospital Affiliated with Jiangsu University 213003 Changzhou China
2 https://ror.org/051jg5p78 Department of Spinal Surgery The Third Affiliated Hospital of Soochow University 213003 Changzhou China
3 https://ror.org/00kkxne40 Department of Orthopedics Suzhou Kowloon Hospital, Shanghai Jiao Tong University School of Medicine 215028 Suzhou China
4 https://ror.org/04fe7hy80 The Wujin Clinical College of Xuzhou Medical University 213003 Changzhou China
5 Changzhou Key Laboratory of Molecular Diagnostics and Precision Cancer Medicine 213003 Changzhou China
Abstract
S100A4 participates in inflammation and immune reactions in the central nervous system and is involved in the pathogenesis of multiple neurological disorders. It can affect the functions of astrocytes, microglia, infiltrating cells and neurons and further modulates neuronal plasticity and survival in the central nervous system. However, its impact on astrocyte phenotypes and neuropathic pain and the intrinsic mechanisms involved remain poorly understood. Here, we showed that...
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