A Case of Corticobasal Syndrome and Posterior Cortical Atrophy With Biomarkers of Alzheimer Disease

  • Published on 15/11/2023
  •  Reading time: 2 min.

Sugimura, Yoko MD*,+; Baba, Toru Md, Phd*; Ezura, Michinori Md, Phd++; Kikuchi, Akio Md, Phd++,[S]; Hasegawa, Takafumi Md, Phd++; Nagano, Isao Md, Phd[//]; Suzuki, Kyoko Md, Phd[P]; Takeda, Atsushi Md, Phd*,+

*Department of Neurology, National Hospital Organization Sendai Nishitaga Hospital
+Department of Cognitive & Motor Aging, Tohoku University Graduate School of Medicine
++Department of Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan
[S]Department of Occupational Therapy, Yamagata Prefectural University of Health Sciences, Yamagata, Japan
[//]Department of Neurology, National Hospital Organization Miyagi Hospital, Watari-gun, Miyagi, Japan
[P]Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan
This work was supported by Grants-in Aid from the Research Committee of CNS Degenerative Diseases, Research on Policy Planning and Evaluation for Rare and Intractable Diseases, Health, Labour and Welfare Sciences Research Grants, the Ministry of Health, Labour and Welfare, Japan.
This study was approved by the institutional review board (Reference number: R2-6), and informed consent was obtained from the patient for publication including videos. We confirm that we have read the Journal's position on issues involved in ethical publication and affirm that this work is consistent with those guidelines.
The authors declare no conflict of interest.
Reprints: Atsushi Takeda, MD, PhD, Department of Neurology, National, Hospital Organization, Sendai Nishitaga Hospital, 2-11-11, Kagitorihoncho, Taihaku-ku, Sendai, Miyagi, Japan1 .
Supplemental Digital Content is available for this article. Direct URL citations are provided in the HTML and PDF versions of this article on the journal's website, www.alzheimerjournal.com.


Corticobasal syndrome is a clinical entity characterized by asymmetric akinetic rigidity and a variety of higher cortical dysfunction. Predicting background pathology of corticobasal syndrome is rather challenging; however, clinical and neuroimaging findings may provide a clue to its etiopathological origin. Visuospatial dysfunction of posterior cortical atrophy and logopenic-type language impairment indicate the presence of Alzheimer's disease-related pathology, and they provide...


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