Cortical and ventricular brain retention of C‐PIB assessed by dynamic PET/CT and correlation with the Aβ1‐42/Aβ1‐40 ratio of amyloid peptides in the cerebral spinal fluid. Preliminary analysis in a healthy control volunteer population
- Published on 01/08/2025
- Reading time: 4 min.
Julio F Jiménez‐Bonilla 1, Francisco J Gómez de la Fuente 1, Sara López‐García 2, María De Arcocha‐Torres 1, Virginia J Mendi‐Barcina 1, Carmen J Lage 1, Francisco J Martínez‐Dubarbie 1, Remedios J Quirce 1
1 Universitary Hospital M Valdecilla, Santander, Cantabria Spain
2 Hospital Universitario Marqués de Valdecilla – IDIVAL – University of Cantabria, Santander, Cantabria Spain
Abstract
Background Preclinical Alzheimer’s disease may be linked to impaired cerebral amyloid clearance. We aim to obtain dynamic parameters of cortical and ventricular clearance of 11C‐PIB and compare them with CSF amyloid values in a population of healthy volunteers.
Method We evaluated 8 healthy volunteers (4 men and mean age: 64.2 years) without neurological or cognitive alterations by a dynamic PET/CT for 45' starting 40 min after administration...
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