Simultaneous Increase of Mean Susceptibility and Mean Kurtosis in the Substantia Nigra as an MRI Neuroimaging Biomarker for Early‐Stage Parkinson's Disease: A Systematic Review and Meta‐Analysis
- Published on 09/04/2024
- Reading time: 4 min.
Sana Mohammadi MD 1, Sadegh Ghaderi PhD 1,2, Hossein Mohammadi PhD 3, Farzad Fatehi MD, MSc 1,4
1
Neuromuscular Research Center, Department of Neurology, Shariati Hospital
Tehran University of Medical Sciences
Tehran
Iran
2
Department of Neuroscience and Addiction Studies, School of Advanced Technologies in Medicine
Tehran University of Medical Sciences
Tehran
Iran
3
Department of Bioimaging, School of Advanced Technologies in Medicine
Isfahan University of Medical Sciences (IUMS)
Isfahan
Iran
4
Neurology Department
University Hospitals of Leicester NHS Trust
Leicester
UK
Abstract
Background Parkinson's disease (PD) is the second most common neurodegenerative disorder. Early detection is crucial for treatment and slowing disease progression.
Hypothesis Simultaneous alterations in mean susceptibility (MS) from quantitative susceptibility mapping (QSM) and mean kurtosis (MK) from diffusion kurtosis imaging (DKI) can serve as reliable neuroimaging biomarkers for early‐stage PD (ESPD) in the basal ganglia nuclei, including the...
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