Correlation Between Atherosclerotic Carotid Plaque Composition and the Neuropathological Lesions of Alzheimer’s Disease: Partial Results
- Published on 01/08/2025
- Reading time: 4 min.
Maria Eduarda Barbosa 1, Renata Elaine Paraizo Leite 2,3, Lea T. Grinberg 4, Ricardo Nitrini 5, Carlos Augusto Pasqualucci 3, Wilson Jacob‐Filho 2,6, Daniela Souza Farias‐Itao 7, Beatriz Carvalho Pontes 3, Maria Eduarda Braga 3, Alberto Fernando Oliveira Justo 8,9, Claudia Kimie Suemoto 8,9,10
1 University of São Paulo Medical School, São Paulo, Selecione Brazil
2 Biobank for aging studies of the University of São Paulo, São Paulo Brazil
3 University of São Paulo Medical School, São Paulo Brazil
4 Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA USA
5 Cognitive and Behavioral Neurology Unit ‐ University of São Paulo, São Paulo Brazil
6 Faculdade de Medicina da Universidade de São Paulo, São Paulo Brazil
7 University of Sao Paulo, Sao Paulo Brazil
8 Biobank for Aging Studies of the University of São Paulo, São Paulo Brazil
9 University of São Paulo Medical School, São Paulo, São Paulo Brazil
10 Division of Geriatrics, Department of Internal Medicine, University of Sao Paulo Medical School, São Paulo, São Paulo Brazil
Abstract
Background Previous studies suggest an association between Alzheimer’s disease and carotid artery atherosclerosis. However, the association between atherosclerotic carotid plaque composition and Alzheimer’s disease pathology (neuritic plaques and neurofibrillary tangles) has not been explored yet.
Method Carotid arteries were dissected and the segments with the largest obstruction in the carotid bifurcation, and the common and internal carotid...
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