Longitudinal follow‐up and prognostic factors in nitrous oxide‐induced neuropathy

  • Published on 06/05/2024
  •  Reading time: 5 min.

Etienne Fortanier 1, Emilien Delmont 1, Giovanni Corazza 1, Ludivine Kouton 1, Joelle Micallef 2, Shahram Attarian 1,3

1 Reference Center for Neuromuscular Diseases and ALS La Timone University Hospital, Aix‐Marseille University Marseille France
2 Clinical Pharmacology and Pharmacosurveillance, Regional Addictovigilance Center of Marseille Marseille University, Hospital Marseille France
3 Inserm, GMGF Aix‐Marseille University Marseille France


Background and Aim Recreational use of nitrous oxide (N2O) has been associated with the development of severe nitrous oxide‐induced neuropathy (N2On). Follow‐up of these patients poses challenges, and their clinical progression remains largely unknown. The identification of prognostic factors is made difficult by the lack of standardized longitudinal assessments in most studies. The objective was to document the course of neuropathy...


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