Genicular Nerve Ultrasound-Guided Cryoanalgesia for the Treatment of Chronic Knee Joint Pain: An Observational Retrospective Study

  • Published on 04/09/2025
  •  Reading time: 4 min.

Giuliano Lo Bianco   1 , Francesco Paolo D’angelo 2 , Christopher L. Robinson 7  

1 Anesthesiology and Pain Department, Foundation G. Giglio Cefalù, Via Pietrapollastra, 90015, Palermo, Cefalù, Italy
2 Department of Anaesthesia, Intensive Care and Emergency, University Hospital Policlinico Paolo Giaccone, Palermo, Italy
7 Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

Abstract

Introduction Chronic knee pain caused by osteoarthritis (OA) is a prevalent source of disability in the adult population. Total knee arthroplasty (TKA) is an effective surgical treatment for advanced disease, but many patients continue to suffer from chronic post-surgical pain (CPSP). In recent years, minimally invasive techniques targeting peripheral nerves have been explored. Cryoanalgesia of the genicular nerves (GNCryo) is one such intervention that disrupts sensory...

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