MRI Investigation of the Association of Left Atrial and Left Atrial Appendage Hemodynamics with Silent Brain Infarction
- Published on 03/27/2024
- Reading time: 5 min.
Maurice Pradella MD 1,2, Justin J. Baraboo MSc 1, Shyam Prabhakaran MD 3, Lihui Zhao PhD 4, Tarek Hijaz MD 1, Erin N. McComb MD 1, Michelle J. Naidich MD 1, Susan R. Heckbert MD, PhD 5, Ilya M. Nasrallah MD, PhD 6, R. Nick Bryan MD, PhD 6, Rod S. Passman MD, MSCE 7,8, Michael Markl PhD 1, Philip Greenland MD 4,7,8
1
Department of Radiology
Northwestern University Feinberg School of Medicine
Chicago
Illinois
USA
2
Department of Radiology
University Hospital Basel, University of Basel
Basel
Switzerland
3
Department of Neurology
University of Chicago
Chicago
Illinois
USA
4
Department of Preventive Medicine
Northwestern University Feinberg School of Medicine
Chicago
Illinois
USA
5
Department of Epidemiology
University of Washington
Seattle
Washington
USA
6
Department of Radiology
University of Pennsylvania
Philadelphia
Pennsylvania
USA
7
Department of Medicine
Northwestern University Feinberg School of Medicine
Chicago
Illinois
USA
8
Division of Cardiology
Northwestern University Feinberg School of Medicine
Chicago
Illinois
USA
Abstract
Background Left atrial (LA) myopathy is thought to be associated with silent brain infarctions (SBI) through changes in blood flow hemodynamics leading to thrombogenesis. 4D‐flow MRI enables in‐vivo hemodynamic quantification in the left atrium (LA) and LA appendage (LAA).
Purpose To determine whether LA and LAA hemodynamic and volumetric parameters are associated with SBI.
Study Type Prospective observational study.
Population...
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