MRI Investigation of the Association of Left Atrial and Left Atrial Appendage Hemodynamics with Silent Brain Infarction

  • Published on 03/27/2024
  •  Reading time: 5 min.

Maurice Pradella MD 1,2, Justin J. Baraboo MSc 1, Shyam Prabhakaran MD 3, Lihui Zhao PhD 4, Tarek Hijaz MD 1, Erin N. McComb MD 1, Michelle J. Naidich MD 1, Susan R. Heckbert MD, PhD 5, Ilya M. Nasrallah MD, PhD 6, R. Nick Bryan MD, PhD 6, Rod S. Passman MD, MSCE 7,8, Michael Markl PhD 1, Philip Greenland MD 4,7,8

1 Department of Radiology Northwestern University Feinberg School of Medicine Chicago Illinois USA
2 Department of Radiology University Hospital Basel, University of Basel Basel Switzerland
3 Department of Neurology University of Chicago Chicago Illinois USA
4 Department of Preventive Medicine Northwestern University Feinberg School of Medicine Chicago Illinois USA
5 Department of Epidemiology University of Washington Seattle Washington USA
6 Department of Radiology University of Pennsylvania Philadelphia Pennsylvania USA
7 Department of Medicine Northwestern University Feinberg School of Medicine Chicago Illinois USA
8 Division of Cardiology Northwestern University Feinberg School of Medicine Chicago Illinois USA

Abstract

Background Left atrial (LA) myopathy is thought to be associated with silent brain infarctions (SBI) through changes in blood flow hemodynamics leading to thrombogenesis. 4D‐flow MRI enables in‐vivo hemodynamic quantification in the left atrium (LA) and LA appendage (LAA).
Purpose To determine whether LA and LAA hemodynamic and volumetric parameters are associated with SBI.
Study Type Prospective observational study.
Population...

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