Fucoidan reduces NET accumulation and alleviates chemotherapy-induced peripheral neuropathy via the gut–blood–DRG axis
- Published on 04/09/2025
- Reading time: 8 min.
Jia Rumeng 1, Wan Li 2, Jin Lai 1, Tian Qingyan 1, Chen Yongyi 5, Zhu Xia 4, Zhang Mengyao 1, Zhang Yajie 3, Zong Lijuan 1, Wu Xuefeng 2, Miao Chen 6, Cai Yihang 1, Ma Jianxin 4, Hu Liang 1, Liu Wen-Tao 1
1 https://ror.org/059gcgy73 Department of Pharmacology, School of Basic Medical Sciences Nanjing Medical University 211166 Nanjing Jiangsu China
2 https://ror.org/01rxvg760 State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences Nanjing University 210023 Nanjing Jiangsu China
3 https://ror.org/04523zj19 Central Laboratory, Department of Biobank Nanjing Hospital of Chinese Medicine, Nanjing University of Chinese Medicine 210022 Nanjing Jiangsu China
4 Department of Oncology Lianyungang Municipal Oriental Hospital 222042 Lianyungang Jiangsu China
5 https://ror.org/03108sf43 Department of Anesthesiology The Affiliated Cancer Hospital of Nanjing Medical University & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research 210009 Nanjing Jiangsu China
6 https://ror.org/04py1g812 Department of Pathology The First Affiliated Hospital of Nanjing Medical University Nanjing Jiangsu China
Abstract
Background Chemotherapy-induced peripheral neuropathy (CIPN) is a serious adverse reaction to chemotherapy with limited treatment options. Research has indicated that neutrophil extracellular traps (NETs) are critical for the pathogenesis of CIPN. LPS/HMGB1 serve as important inducers of NETs. Here, we aimed to target the inhibition of NET formation (NETosis) to alleviate CIPN.
Methods Oxaliplatin (L-OHP) was used to establish a CIPN model. The mice were...
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