Fractional excretion of urea nitrogen can identify true worsening renal function in patients with heart failure

Published on 04/01/2024

Reading time: 5 min.

Yukihiro Watanabe ¹, Yoshiaki Kubota¹, Takuya Nishino², Shuhei Tara¹, Katsuhito Kato³, Daisuke Hayashi⁴, Junya Matsuda¹, Hideki Miyachi^1,5, Yukichi Tokita¹, Yu‐ki Iwasaki¹, Kuniya Asai¹

¹ Department of Cardiovascular Medicine Nippon Medical School Tokyo Japan
² Department of Health Care Administration Nippon Medical School Tokyo Japan
³ Department of Hygiene and Public Health Nippon Medical School Tokyo Japan
⁴ Department of Pharmaceutical Service Nippon Medical School Hospital Tokyo Japan
⁵ Division of Cardiovascular Intensive Care Nippon Medical School Hospital Tokyo Japan

Abstract

Aims Fractional excretion of urea nitrogen (FEUN), used to differentiate the cause of acute kidney injury, has emerged as a useful fluid index in patients with heart failure (HF). We hypothesized that FEUN could be useful in identifying worsening renal function (WRF) associated with poor outcomes in patients with acute HF (AHF).
Methods and results Overall, 1103 patients with AHF (median age, 78 years; male proportion, 60%) were categorized into six groups...

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ESC heart failure

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