Joint Analysis of Multiple Omics to Describe the Biological Characteristics of Resistant Hypertension

  • Published on 01/06/2025
  •  Reading time: 7 min.

Shanshan Wang1,2, Yuanlong Hu3, Yuqi Wang3, Yueyue Song1, Dan Liang1, Jiufeng Yin1, Yunlun Li1,4,5, Wenqing Yang 1,4, Dan Zhang 6,7

1 Innovative Institute of Chinese Medicine and Pharmacy Shandong University of Traditional Chinese Medicine Jinan China
2 Department of Cardiology The Fifth People's Hospital of Jinan Jinan China
3 First Faculty of Clinical Medicine Shandong University of Traditional Chinese Medicine Jinan China
4 Shandong Engineering Laboratory of Traditional Chinese Medicine Precise Therapy for Cardiovascular Diseases Jinan China
5 Department of Cardiology Affiliated Hospital of Shandong University of Traditional Chinese Medicine Jinan China
6 Experimental Center Shandong University of Traditional Chinese Medicine Jinan China
7 Key Laboratory of Traditional Chinese Medicine Classical Theory Ministry of Education Shandong University of Traditional Chinese Medicine Jinan China

Abstract

Resistant hypertension (RH) may cause severe target organ damage and poses significant challenges in the field of hypertension prevention and treatment. Mining biological characteristics is crucial for exploring the pathogenesis of RH and for early diagnosis and treatment. Although several single‐omics studies have been conducted on RH, its complex pathogenesis has only been partially elucidated. In this study, metabolomics, proteomics, and transcriptomics were jointly...

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